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Pancreatic Surgery & Transplant
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| Thomas E. Starzl |
Sir Roy Calne |
Dr. Subash & Dr. Tanaka |
Sir Roy Calne
As recently as 40 years ago, organ transplantation was still a distant dream. Since then it has been transformed into a major branch of surgery and a valuable form of treatment.
One of the figures most responsible for this transformation is Sir Roy Calne,Professor of Surgery at the University of Cambridge. Calne began his research on organ transplantation in 1959 at the Royal Free Hospital, and described the first effective immunosuppression for experimental kidney transplantation. He developed this approach further while working as a Harkness Fellow at the Peter Bent Brigham Hospital in Boston, Massachusetts, where it was applied to the treatment of patients in 1962.In 1977,
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Calne developed the immunosuppressive agent cyclosporine A and introduced it into clinical practice in 1978. This breakthrough is reflected in his highly cited papers--most notably, a 1984 report discussing cyclosporine in renal transplantation. (See R.M. Merion et al., "Cyclosporine: Five years experience in cadaveric renal transplantation," New Engl. J. Med., 310[3]:148-54, 1984. This paper has been cited nearly 300 times since its publication).
In 1968 Calne performed the first liver transplant in Europe; in 1987, the world's first liver, heart, and lung transplant; in 1992, the first intestinal transplant in the U.K.; and in 1994, the first successful combined stomach, intestine, pancreas, liver, and kidney cluster transplant.
In addition to his duties at the University of Cambridge, Calne is also an Honorary Consultant Surgeon at Addenbrooke's Hospital, Cambridge, and is Immediate Past President of the Transplantation Society. Aside from his research, he has other, wide-ranging interests. For example, he is an artist whose paintings, depicting images of his clinical work, have been exhibited in many countries to help promote awareness of transplantation. In 1994, adding to his roster of textbooks on surgery and transplantation, he wrote a book entitled Too Many People, which warns of the dangers of the continuing, rapid growth in the world's population.
Calne, 64, was educated at Lancing College and received his medical training at Guy's Hospital, London. He was elected a Fellow of the Royal Society in 1973, and was knighted in 1986.
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